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Prognostic value of medulloblastoma extent of resection after accounting for molecular subgroup: a retrospective integrated clinical and molecular analysis.

Eric M Thompson | Thomas Hielscher | Eric Bouffet | Marc Remke | Betty Luu | Sridharan Gururangan | Roger E McLendon | Darell D Bigner | Eric S Lipp | Sebastien Perreault | Yoon-Jae Cho | Gerald Grant | Seung-Ki Kim | Ji Yeoun Lee | Amulya A Nageswara Rao | Caterina Giannini | Kay Ka Wai Li | Ho-Keung Ng | Yu Yao | Toshihiro Kumabe | Teiji Tominaga | Wieslawa A Grajkowska | Marta Perek-Polnik | David C Y Low | Wan Tew Seow | Kenneth T E Chang | Jaume Mora | Ian F Pollack | Ronald L Hamilton | Sarah Leary | Andrew S Moore | Wendy J Ingram | Andrew R Hallahan | Anne Jouvet | Michelle Fèvre-Montange | Alexandre Vasiljevic | Cecile Faure-Conter | Tomoko Shofuda | Naoki Kagawa | Naoya Hashimoto | Nada Jabado | Alexander G Weil | Tenzin Gayden | Takafumi Wataya | Tarek Shalaby | Michael Grotzer | Karel Zitterbart | Jaroslav Sterba | Leos Kren | Tibor Hortobágyi | Almos Klekner | Bognár László | Tímea Pócza | Peter Hauser | Ulrich Schüller | Shin Jung | Woo-Youl Jang | Pim J French | Johan M Kros | Marie-Lise C van Veelen | Luca Massimi | Jeffrey R Leonard | Joshua B Rubin | Rajeev Vibhakar | Lola B Chambless | Michael K Cooper | Reid C Thompson | Claudia C Faria | Alice Carvalho | Sofia Nunes | José Pimentel | Xing Fan | Karin M Muraszko | Enrique López-Aguilar | David Lyden | Livia Garzia | David J H Shih | Noriyuki Kijima | Christian Schneider | Jennifer Adamski | Paul A Northcott | Marcel Kool | David T W Jones | Jennifer A Chan | Ana Nikolic | Maria Luisa Garre | Erwin G Van Meir | Satoru Osuka | Jeffrey J Olson | Arman Jahangiri | Brandyn A Castro | Nalin Gupta | William A Weiss | Iska Moxon-Emre | Donald J Mabbott | Alvaro Lassaletta | Cynthia E Hawkins | Uri Tabori | James Drake | Abhaya Kulkarni | Peter Dirks | James T Rutka | Andrey Korshunov | Stefan M Pfister | Roger J Packer | Vijay Ramaswamy | Michael D Taylor
The Lancet. Oncology | 2016

Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific manner.

Pubmed ID: 26976201 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P50 CA190991
  • Agency: NCI NIH HHS, United States
    Id: R01 CA159859
  • Agency: CIHR, Canada
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS096236
  • Agency: NCI NIH HHS, United States
    Id: R01 CA163737
  • Agency: NCI NIH HHS, United States
    Id: R01 CA148621
  • Agency: NCI NIH HHS, United States
    Id: R01 CA148699
  • Agency: NCI NIH HHS, United States
    Id: F31 CA203372
  • Agency: NCI NIH HHS, United States
    Id: R01 CA163722

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ggplot2 (tool)

RRID:SCR_014601

Open source software package for statistical programming language R to create plots based on grammar of graphics. Used for data visualization to break up graphs into semantic components such as scales and layers.

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