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Novel mutations in LRP6 highlight the role of WNT signaling in tooth agenesis.

Genetics in medicine : official journal of the American College of Medical Genetics | 2016

We aimed to identify a novel genetic cause of tooth agenesis (TA) and/or orofacial clefting (OFC) by combining whole-exome sequencing (WES) and targeted resequencing in a large cohort of TA and OFC patients.

Pubmed ID: 26963285 RIS Download

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Associated grants

  • Agency: Medical Research Council, United Kingdom
    Id: G0901539
  • Agency: NHGRI NIH HHS, United States
    Id: U54 HG006542
  • Agency: NHGRI NIH HHS, United States
    Id: UM1 HG006542
  • Agency: Medical Research Council, United Kingdom
    Id: MR/M012174/1
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS058529

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