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Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.

Neurology | 2016

For 3,670 stroke patients from the United Kingdom, United States, Australia, Belgium, and Italy, we performed a genome-wide meta-analysis of white matter hyperintensity volumes (WMHV) on data imputed to the 1000 Genomes reference dataset to provide insights into disease mechanisms.

Pubmed ID: 26674333 RIS Download

Research resources used in this publication

None found

Additional research tools detected in this publication

Antibodies used in this publication

None found

Associated grants

  • Agency: NINDS NIH HHS, United States
    Id: R01 NS017950
  • Agency: NIA NIH HHS, United States
    Id: R01 AG054076
  • Agency: Wellcome Trust, United Kingdom
    Id: 095626
  • Agency: Wellcome Trust, United Kingdom
    Id: 104040
  • Agency: NINDS NIH HHS, United States
    Id: R01 NS085419
  • Agency: NIA NIH HHS, United States
    Id: R01 AG008122
  • Agency: NIA NIH HHS, United States
    Id: R01 AG033193
  • Agency: Medical Research Council, United Kingdom
    Id: G0900295
  • Agency: NCATS NIH HHS, United States
    Id: UL1 TR001425
  • Agency: NIA NIH HHS, United States
    Id: P30 AG010129
  • Agency: Medical Research Council, United Kingdom
    Id: G0500247
  • Agency: Medical Research Council, United Kingdom
    Id: MR/K026992/1

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This is a list of tools and resources that we have found mentioned in this publication.


PLINK (tool)

RRID:SCR_001757

Open source whole genome association analysis toolset, designed to perform range of basic, large scale analyses in computationally efficient manner. Used for analysis of genotype/phenotype data. Through integration with gPLINK and Haploview, there is some support for subsequent visualization, annotation and storage of results. PLINK 1.9 is improved and second generation of the software.

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MRIcro Software (tool)

RRID:SCR_008264

MRIcro allows Windows and Linux computers view medical images. It is a standalone program, but includes tools to complement SPM (software that allows neuroimagers to analyze MRI, fMRI and PET images). MRIcro allows efficient viewing and exporting of brain images. In addition, it allows neuropsychologists to identify regions of interest (ROIs, e.g. lesions). MRIcro can create Analyze format headers for exporting brain images to other platforms. Some features of MRIcro are: - Converts medical images to SPM friendly Analyze format. - View Analyze format images (big or little endian). - Create Analyze format headers (big or little endian). - Create 3D regions of interest (with computed volume & intensity). - Overlap multiple regions of interest. - Rotate images to match SPM template images. - Export images to BMP, JPEG, PNG or TIF format. - Yoked images: linked viewing of multiple images (e.g. view same coordinates of PET and MRI scans). Users familiar with other Windows programs will find that this software is fairly straightforward to use. Resting the mouse cursor over a button will cause a text hint to appear over the button. However, a tutorial with a step by step guide of how to use MRIcro with SPM is available.

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IMPUTE (tool)

RRID:SCR_009245

Software application for estimating (imputing) unobserved genotypes in SNP association studies. The program is designed to work seamlessly with the output of the genotype calling program CHIAMO and the population genetic simulator HAPGEN, and it produces output that can be analyzed using the program SNPTEST. (entry from Genetic Analysis Software)

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