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Melanopsin retinal ganglion cell loss in Alzheimer disease.

Annals of neurology | 2016

Melanopsin retinal ganglion cells (mRGCs) are photoreceptors driving circadian photoentrainment, and circadian dysfunction characterizes Alzheimer disease (AD). We investigated mRGCs in AD, hypothesizing that they contribute to circadian dysfunction.

Pubmed ID: 26505992 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NIA NIH HHS, United States
    Id: P50 AG005142
  • Agency: NIA NIH HHS, United States
    Id: P50-AG05142
  • Agency: NIA NIH HHS, United States
    Id: R41 AG044897
  • Agency: NEI NIH HHS, United States
    Id: P30 EY003040
  • Agency: NEI NIH HHS, United States
    Id: EY03040
  • Agency: NIA NIH HHS, United States
    Id: R41 AG044897-01

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Alzheimer's and Dementia Resource Center (tool)

RRID:SCR_004924

The Alzheimer's and Dementia Resource Center (ADRC) facilitates tissue donations for the Brain Bank Research Program in order to help find better treatments, more diagnostic tools and a cure for Alzheimer's disease and dementia. The Brain Bank Program is administered by Mount Sinai Medical Center in Miami Beach and under contract with the Florida Department of Elder Affairs. ADRC also provides caregivers with the educational resources, spiritual comfort and emotional support. The ADRC facilitates training for professional caregivers that meets requirements for the Florida Department of Elder Affairs.

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AutoQuant (tool)

RRID:SCR_002465

Software package of 2D and 3D restoration algorithms.Advanced image deconvolution and 3D visualization software for Life Science Researchers.

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Imaris (tool)

RRID:SCR_007370

Imaris provides range of capabilities for working with three dimensional images. Uses flexible editing and processing functions, such as interactive surface rendering and object slicing capabilities. And output to standard TIFF, Quicktime and AVI formats. Imaris accepts virtually all image formats that are used in confocal microscopy and many of those used in wide-field image acquisition.

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