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Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells.

Molecular cancer | 2015

Compromised colonic butyrate production resulting from low dietary fiber or altered gut microbiota may promote colon neoplasia. Previous reports indicate these actions are mediated in part by altered levels of miRNAs, including suppressed expression of the oncogenic miR-17-92a cluster. Here, we sought to identify the mechanisms underlying these effects of butyrate in colon cancer.

Pubmed ID: 26463716 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK042086
  • Agency: NIDDK NIH HHS, United States
    Id: R21 DK093406
  • Agency: NIDDK NIH HHS, United States
    Id: DK067872
  • Agency: BLRD VA, United States
    Id: I01 BX000332
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK057819
  • Agency: NIDDK NIH HHS, United States
    Id: DK093406
  • Agency: NIDDK NIH HHS, United States
    Id: DK42086
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK068491
  • Agency: NIDDK NIH HHS, United States
    Id: R37 DK047722
  • Agency: NIDDK NIH HHS, United States
    Id: DK57819
  • Agency: NIDDK NIH HHS, United States
    Id: DK61972
  • Agency: NIDDK NIH HHS, United States
    Id: DK47722
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK061972
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK097268
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK047722
  • Agency: NIDDK NIH HHS, United States
    Id: T32 DK067872

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