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CpG hypermethylation in gene promoters is a frequent mechanism of tumor suppressor gene silencing in various types of cancers. It usually occurs at early steps of cancer progression and can be detected easily, giving rise to development of promising biomarkers for both detection and progression of cancer, including breast cancer. 5-aza-2'-deoxycytidine (AZA) is a DNA demethylating and anti-cancer agent resulting in induction of genes suppressed via DNA hypermethylation.
Pubmed ID: 26421063 RIS Download
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You can easily align, visualize and quantify bisulfite sequence data for CpG methylation analysis.
View all literature mentionsAn integrated software package for the visualization and statistical analysis of DNA microarray gene expression data.
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