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Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice.

Journal of acquired immune deficiency syndromes (1999) | 2015

Recent reports showed that functional control of HIV-1 infection for a prolonged time is possible by early antiretroviral therapy (ART); however, its underlying mechanism needs to be studied with a suitable animal model. Recently, humanized-BLT (bone marrow, liver, and thymus) mouse (hu-BLT) was shown to be an excellent model for studying HIV-1 infection. We thus tested the feasibility of studying functional control of HIV-1 infection using hu-BLT mice.

Pubmed ID: 26167617 RIS Download

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Associated grants

  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK087625
  • Agency: FIC NIH HHS, United States
    Id: D43 TW001429
  • Agency: FIC NIH HHS, United States
    Id: F43 TW 001429
  • Agency: NIGMS NIH HHS, United States
    Id: P30 GM103509
  • Agency: NIAID NIH HHS, United States
    Id: R01 AI111862

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Depleting anti-CD8a (antibody)

RRID:AB_2716320

This monoclonal targets CD8a chain protein

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Depleting anti-CD8a (antibody)

RRID:AB_2716320

This monoclonal targets CD8a chain protein

View all literature mentions