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Targeting class I histone deacetylase 2 in MYC amplified group 3 medulloblastoma.

Acta neuropathologica communications | 2015

Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Four subgroups with distinct genetic, epigenetic and clinical characteristics have been identified. Survival remains particularly poor in patients with Group 3 tumors harbouring a MYC amplification. We herein explore the molecular mechanisms and translational implications of class I histone deacetylase (HDAC) inhibition in MYC driven MBs.

Pubmed ID: 25853389 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: P50 CA086355
  • Agency: NCI NIH HHS, United States
    Id: P50CA086355

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