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Publication

Nrf2 regulates ROS production by mitochondria and NADPH oxidase.

Biochimica et biophysica acta | 2015

Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription factor mediating protection against oxidants. Nrf2 is negatively regulated by cytoplasmic Kelch-like ECH associated protein 1 (Keap1) thereby providing inducible antioxidant defence. Antioxidant properties of Nrf2 are thought to be mainly exerted by stimulating transcription of antioxidant proteins, whereas its effects on ROS production within the cell are uncertain.

Pubmed ID: 25484314 RIS Download

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Associated grants

  • Agency: Cancer Research UK, United Kingdom
    Id: 10270
  • Agency: Wellcome Trust, United Kingdom
    Id: 089698
  • Agency: Cancer Research UK, United Kingdom
    Id: C20953/A10270
  • Agency: Medical Research Council, United Kingdom
    Id: MC_G1000735
  • Agency: Wellcome Trust, United Kingdom

Publication data is provided by the National Library of Medicine ® and PubMed ®. Data is retrieved from PubMed ® on a weekly schedule. For terms and conditions see the National Library of Medicine Terms and Conditions.

This is a list of tools and resources that we have found mentioned in this publication.

B6.129X1-Nfe2l2tm1Ywk/J (tool)

RRID:IMSR_JAX:017009

Mus musculus with name B6.129X1-Nfe2l2tm1Ywk/J from IMSR.

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