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The neurotrophin receptor p75 regulates gustatory axon branching and promotes innervation of the tongue during development.

Neural development | 2014

Brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT4) regulate the survival of gustatory neurons, axon growth and branching, and innervation of taste buds during development. These actions are largely, but not completely, mediated through the tyrosine kinase receptor, TrkB. Here, we investigated the role of p75, the other major receptor for BDNF and NT4, in the development of the taste system.

Pubmed ID: 24961238 RIS Download

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Associated grants

  • Agency: NIGMS NIH HHS, United States
    Id: 8P30GM103507
  • Agency: NIDCD NIH HHS, United States
    Id: DC009418

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RRID:SCR_001224

A contract research organization providing drug development and animal testing services. Under the name Covance Research Products Inc., based in Denver, Pennsylvania, the company also deals in the import, breeding and sale of laboratory animals. It breeds dogs, rabbits, guinea pigs, non-human primates, and pigs, and runs the largest non-human primate laboratory in Germany. (Wikipedia)

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