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Neural hyperactivity related to working memory in drug-naive boys with attention deficit hyperactivity disorder.

Progress in neuro-psychopharmacology & biological psychiatry | 2014

Impaired working memory is thought to be a core feature of attention deficit hyperactivity disorder (ADHD). Previous imaging studies investigating working memory in ADHD have used tasks involving different cognitive resources and ignoring the categorical judgments about objects that are essential parts of performance in visual working memory tasks, thus complicating the interpretation of their findings. In the present study, we explored differential neural activation in children and adolescents with ADHD and in healthy controls using functional magnetic resonance imaging (fMRI) with the categorical n-back task (CN-BT), which maximized demands for executive reasoning while holding memory demands constant.

Pubmed ID: 24704944 RIS Download

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