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X-linked adrenoleukodystrophy (X-ALD) is a genetic disorder of X-linked inheritance caused by a mutation in the ABCD1 gene which determines an accumulation of long-chain fatty acids in plasma and tissues. Recent evidence shows that oxidative stress may be a hallmark in the pathogenesis of X-ALD and glutathione plays an important role in the defense against free radicals. In this study we have analyzed glutathione homeostasis in lymphocytes of 14 patients with X-ALD and evaluated the balance between oxidized and reduced forms of glutathione, in order to define the role of this crucial redox marker in this condition.
Pubmed ID: 23768953 RIS Download
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THIS RESOURCE HAS BEEN DISCONTINUED. Documented October 3, 2017. Operational software created by Agilent Technologies to operate with its ChemStation hardware. The software can manage all parameters for instrument control, data acquisition and evaluation, including integration, quantification and reporting.
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