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Site specific cleavage mediated by MMPs regulates function of agrin.

PloS one | 2012

Agrin is the key inducer of postsynaptic differentiations at the neuromuscular junction. The multidomain heparan sulfate proteoglycan is mediating via its N-terminal segment the interaction with laminin, whereas the C-terminal portion is responsible for Dystroglycan binding and clustering of the Acetylcholine receptor. Matrix metalloproteinases (MMP) are known to play essential roles in matrix remodeling, degradation and regulation of extracellular signaling networks.

Pubmed ID: 22984437 RIS Download

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Associated grants

  • Agency: Canadian Institutes of Health Research, Canada

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HEK293 (tool)

RRID:CVCL_0045

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