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The atypical antidepressant mianserin exhibits agonist activity at κ-opioid receptors.

British journal of pharmacology | 2012

Antidepressants are known to interact with the opioid system through mechanisms not completely understood. We previously reported that tricyclic antidepressants act as agonists at distinct opioid receptors. Here, we investigated the effect of the atypical antidepressant mianserin at cloned and native opioid receptors.

Pubmed ID: 22708686 RIS Download

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