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The safety, effectiveness and concentrations of adjusted lopinavir/ritonavir in HIV-infected adults on rifampicin-based antitubercular therapy.

PloS one | 2012

Rifampicin co-administration dramatically reduces plasma lopinavir concentrations. Studies in healthy volunteers and HIV-infected patients showed that doubling the dose of lopinavir/ritonavir (LPV/r) or adding additional ritonavir offsets this interaction. However, high rates of hepatotoxicity were observed in healthy volunteers. We evaluated the safety, effectiveness and pre-dose concentrations of adjusted doses of LPV/r in HIV infected adults treated with rifampicin-based tuberculosis treatment.

Pubmed ID: 22412856 RIS Download

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Associated grants

  • Agency: FIC NIH HHS, United States
    Id: U2R TW007370
  • Agency: PHS HHS, United States
    Id: U2RTW007370/3
  • Agency: PHS HHS, United States
    Id: U2RTW007373
  • Agency: FIC NIH HHS, United States
    Id: U2R TW007373
  • Agency: PHS HHS, United States
    Id: 5U2RTW007373

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