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Retinoid X receptors (RXR) are transcription factors with important roles in development, reproduction, homeostasis, and cell differentiation. Different types of vertebrate RXRs (α (RXRA), ß (RXRB) and γ (RXRG)) have arisen from multiple duplication events. The adaptive evolution mechanism that has preserved duplicate RXR paralogs, as well as their role in development and adaptation, is thus far unknown. In this work, we have investigated different aspects of vertebrate RXR evolution. Codon based tests of positive selection identified that RXR was under significant positive selection immediately after the whole genome duplications in vertebrates. Amino acid based rate shift analysis also revealed significant rate shifts immediately after the whole genome duplications and functional divergence between all the pairs of RXRs. However, the extant RXR genes are highly conserved, particularly the helix involved in dimerization and the DNA-binding domain, but positively selected sites can nevertheless be found in domains for RXR regulation.
Pubmed ID: 22193333 RIS Download
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Collaborative research network specializing in urological chronic pelvic pain disorders. Project involves conducting research primarily on interstitial cystitis/painful bladder syndrome and chronic prostatitis/chronic pelvic pain syndrome and involves researchers from multiple disciplines. MAPP Network includes researchers with clinical, epidemiological, and basic research expertise.
View all literature mentionsGraphical user interface for multiple sequence alignment and molecular phylogeny. SeaView also generates phylogenetic trees.
View all literature mentionsSoftware that eliminates poorly aligned positions and divergent regions of a DNA or protein alignment so that it becomes more suitable for phylogenetic analysis.
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