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Head size markedly differs among individuals. To our knowledge, there have been no studies that systematically investigated the effect of head size on diffusion tensor measures of the brain. The purpose of this study was to evaluate the effect of head size or total intracranial volume on diffusion tensor measures (FA and MD). A total of 821 normal subjects (304 females and 517 males) were included in this study. We investigated the effect of total intracranial volume on FA and MD mainly using tract-based spatial statistics (TBSS). There were a number of regions where FA or MD was significantly correlated with total intracranial volume. There was no significant interaction between total intracranial volume and sex. The results indicate that total intracranial volume significantly influences diffusion tensor measures such as FA and MD. The possible explanations of the relationship between diffusion tensor measures and total intracranial volume may be 'partial volume effects' or micro-architectural differences related to head size. When total intracranial volumes are significantly different between groups, it may be necessary to control for total intracranial volume in the statistical analysis, depending on the hypothesis being tested.
Pubmed ID: 21605689 RIS Download
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Open source software suite for processing and analyzing human brain MRI images. Used for reconstruction of brain cortical surface from structural MRI data, and overlay of functional MRI data onto reconstructed surface. Contains automatic structural imaging stream for processing cross sectional and longitudinal data. Provides anatomical analysis tools, including: representation of cortical surface between white and gray matter, representation of the pial surface, segmentation of white matter from rest of brain, skull stripping, B1 bias field correction, nonlinear registration of cortical surface of individual with stereotaxic atlas, labeling of regions of cortical surface, statistical analysis of group morphometry differences, and labeling of subcortical brain structures.Operating System: Linux, macOS.
View all literature mentionsSoftware library of image analysis and statistical tools for fMRI, MRI and DTI brain imaging data. Include registration, atlases, diffusion MRI tools for parameter reconstruction and probabilistic taractography, and viewer. Several brain atlases, integrated into FSLView and Featquery, allow viewing of structural and cytoarchitectonic standard space labels and probability maps for cortical and subcortical structures and white matter tracts. Includes Harvard-Oxford cortical and subcortical structural atlases, Julich histological atlas, JHU DTI-based white-matter atlases, Oxford thalamic connectivity atlas, Talairach atlas, MNI structural atlas, and Cerebellum atlas.
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