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Circadian integration of glutamatergic signals by little SAAS in novel suprachiasmatic circuits.

PloS one | 2010

Neuropeptides are critical integrative elements within the central circadian clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell synchronization and phase adjustments that cause light entrainment. Forward peptidomics identified little SAAS, derived from the proSAAS prohormone, among novel SCN peptides, but its role in the SCN is poorly understood.

Pubmed ID: 20830308 RIS Download

Research resources used in this publication

None found

Antibodies used in this publication

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Associated grants

  • Agency: NIDA NIH HHS, United States
    Id: P30 DA018310
  • Agency: NIDCR NIH HHS, United States
    Id: R01 DE018866
  • Agency: NIA NIH HHS, United States
    Id: T32 MH/AG19957
  • Agency: NHLBI NIH HHS, United States
    Id: HL092571
  • Agency: NHLBI NIH HHS, United States
    Id: R01 HL092571
  • Agency: NIDCR NIH HHS, United States
    Id: DE018866

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MatrixScience (tool)

RRID:SCR_000307

A collection of both commercial and noncommercial software products which includes: Mascot Distiller, Mascot Parser, and Mascot Server. Mascot Distiller is commercial and provides a single interface to process raw data into de-isotoped peak lists. This tool can also be used for the easy distribution of search and quantitative results to colleagues. The non-commercial Mascot Parser software provides an API (Application Programmer Interface) that makes it easier to access search results written in C++, Java, Python and Perl. Mascot Server is non-commercial, and is a collection of peptide mass fingerprints as well as a MS/MS database. A selection of popular sequence databases are available online and include SwissProt, NCBInr, and the EST divisions of EMBL. This server is best used for evaluating and searching for smaller data sets.

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National Institutes of Health (tool)

RRID:SCR_011417

NIH is the nations medical research agency - making important medical discoveries that improve health and save lives. The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the primary Federal agency for conducting and supporting medical research. Helping to lead the way toward important medical discoveries that improve peoples health and save lives, NIH scientists investigate ways to prevent disease as well as the causes, treatments, and even cures for common and rare diseases. NIH research impacts: * child and teen health, * men's health, * minority health, * seniors' health, * women's health, and * wellness and lifestyle issues. Composed of 27 Institutes and Centers, the NIH provides leadership and financial support to researchers in every state and throughout the world.

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RRID:MMRRC_036544-UCD

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