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Genetic variation in the estrogen metabolic pathway and mammographic density as an intermediate phenotype of breast cancer.

Breast cancer research : BCR | 2010

Several studies have examined the effect of genetic variants in genes involved in the estrogen metabolic pathway on mammographic density, but the number of loci studied and the sample sizes evaluated have been small and pathways have not been evaluated comprehensively. In this study, we evaluate the association between mammographic density and genetic variants of the estrogen metabolic pathway.

Pubmed ID: 20214802 RIS Download

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA 128931
  • Agency: NCI NIH HHS, United States
    Id: R01 CA 122340
  • Agency: NCI NIH HHS, United States
    Id: P01 CA87969
  • Agency: NCI NIH HHS, United States
    Id: R01 CA065725
  • Agency: NCI NIH HHS, United States
    Id: R01 CA131332
  • Agency: NCI NIH HHS, United States
    Id: R01 CA122340
  • Agency: NCI NIH HHS, United States
    Id: R01 CA58427

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MACH (tool)

RRID:SCR_009621

QTL analysis based on imputed dosages/posterior_probabilities.

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