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Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment.

PloS one | 2009

Glioblastoma multiforme (GBM) cells secrete large amounts of glutamate that can trigger AMPA-type glutamate receptors (AMPARs). This commonly results in Na(+) and Ca(2+)-permeability and thereby in excitotoxic cell death of the surrounding neurons. Here we investigated how the GBM cells themselves survive in a glutamate-rich environment.

Pubmed ID: 19536293 RIS Download

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oligo (tool)

RRID:SCR_015729

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U-87MG ATCC (tool)

RRID:CVCL_0022

Cell line U-87MG ATCC is a Cancer cell line with a species of origin Homo sapiens (Human)

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