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Single nucleotide polymorphisms (SNPs) distinguish Indian-origin and Chinese-origin rhesus macaques (Macaca mulatta).

BMC genomics | 2007

Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects of their behavior and physiology, including response to simian immunodeficiency virus (SIV) infection. Single nucleotide polymorphisms (SNPs) can play an important role in both establishing ancestry and in identifying genes involved in complex diseases. We sequenced the 3' end of rhesus macaque genes in an effort to identify gene-based SNPs that could distinguish between Indian and Chinese rhesus macaques and aid in association analysis.

Pubmed ID: 17286860 RIS Download

Research resources used in this publication

None found

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Associated grants

  • Agency: NCRR NIH HHS, United States
    Id: P51 RR000163
  • Agency: NCRR NIH HHS, United States
    Id: P51 RR000166
  • Agency: NCRR NIH HHS, United States
    Id: RR017444-04S1
  • Agency: NCRR NIH HHS, United States
    Id: K01 RR000163
  • Agency: NCRR NIH HHS, United States
    Id: RR00166
  • Agency: NCRR NIH HHS, United States
    Id: RR00163-46
  • Agency: NCRR NIH HHS, United States
    Id: R24 RR017444

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Sequencher (tool)

RRID:SCR_001528

Software for Next-Generation DNA sequencing, Sanger DNA analysis, and RNA sequencing. It contains sequence analysis tools which include reference-guided alignments, de novo assembly, variant calling, and SNP analyses. It has integrated the Cufflinks suite for in-depth transcript analysis and differential gene expression of RNA-Seq data.

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dbSNP (tool)

RRID:SCR_002338

Database as central repository for both single base nucleotide substitutions and short deletion and insertion polymorphisms. Distinguishes report of how to assay SNP from use of that SNP with individuals and populations. This separation simplifies some issues of data representation. However, these initial reports describing how to assay SNP will often be accompanied by SNP experiments measuring allele occurrence in individuals and populations. Community can contribute to this resource.

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ONPRC18 Multimodal MRI Atlas (tool)

RRID:SCR_019073

Atlas includes co-registered templates constructed from MR images frequently used to characterize macroscopic brain structure T2/SPACE and T1/MP-RAGE, and diffusion tensor imaging template.

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