URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=10401208
Proper Citation: RRID:RRRC_00699
Description: Rattus norvegicus with name F344-Tg(Prp-APP,Prp-PS1)19/Rrrc from RGD.
Species: Rattus norvegicus
Notes: The strain was coinjected with two transgenes: one contains the human amyloid beta (A4) precursor protein (hAPP) gene with the Swedish mutation (K595N/M596L) driven by mouse prion promoter (Prp). The other contains the human presenilin 1 gene (PS1) with a deletion of exon 9, also driven by the mouse prion promoter (Prp). Based on segregation patterns, it is believed that the two transgenes have integrated at the same chromosomal site. Rat Resource and Research Center
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Source: Integrated Animals
Source Database: Rat Resource and Research Center (RRRC)