Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Functional Analysis Core (RRID:SCR_015386)Copy Citation Copied
URL: https://www.med.unc.edu/marsicolunginstitute/core-facilities/cftr-functional-analysis-core
Proper Citation: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Functional Analysis Core (RRID:SCR_015386)
Description: Core that analyzes ion channel properties and correction efficiency of human bronchial epithelial (HBE) cells from harvested CF lungs to provide a full characterization report to investigators, measures ion transport function of CFTR and ENaC in HBE and human nasal epithelial (HNE) cultures by bioelectric and organoid assays to asses efficacy of candidate therapies, evaluates CFTR expression and processing by biochemical analyses to assess efficacy of CFTR modulation strategies, and validates the suitability of reagents, supplies, and techniques for optimizing HBE and HNE cell integrity.
Resource Type: service resource, access service resource, core facility
Keywords: cystic fibrosis, gene targeting, functional analysis
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University of North Carolina at Chapel Hill School of Medicine; North Carolina; USA |
has parent organization |
Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center |
is organization facet of |
Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center |
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