URL: http://harvard.eagle-i.net/i/0000012e-97d7-0e06-55da-381e80000000
Proper Citation: MGH CHGR Chromosome Substitution Strain Resource (RRID:SCR_009916)
Description:
Core facility that provides the following services: Breeding pair service, Mouse Phenotyping Services.
This resource provides to MGH investigators a local source of breeding pairs of the 22 chromosome substitution strains (CSS)* of mice and access to basic phenotyping equipment for mapping of simple or complex traits, to promote the use of genetic mouse-based strategies in basic and clinical research. The CSS Resource comprises 22 mouse lines, each homozygous for a single A/J chromosome (Chr 1-19, X or Y and mitochondria) on a genetic background that is otherwise C57BL/J that were generated by Dr. Joseph Nadeau (Case Western Reserve University) and his colleagues. The CSS mice are available from The Jackson Laboratories. However, to save time and money, the MGH CSS Resource maintains CSS breeding colonies that are housed in the Simches-8 barrier facility, adjacent to a procedure room that will have equipment for basic standardized phenotyping, including behavioral and metabolic measurements.
Resource Type: service resource, access service resource, core facility
Keywords: mouse breeding, phenotype characterization
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