URL: http://sirecords.umn.edu/siRecords/
Proper Citation: siRecords (RRID:SCR_007928)
Description: On this site, you can search siRNA records, design siRNAs, or submit siRNA records resulting from your own study (requires register/login). Small interfering RNAs (siRNAs) are a class of 20-25 nucleotide-long double-stranded RNAs, and they are widely used as gene knock-down tool in molecular genetics, functional genomics, and drug discovery studies. However, despite numerous efforts, the design of potent siRNA remains inadequate. Design rules resulting from different studies often disagree with each other, and are often unsatisfactory. Typically, only about 75-80% siRNAs designed based on current rules result in >50% knock-down efficacy. Observing these difficulties, we have established this database of experimentally validated mammalian siRNAs with efficacy ratings. As of August 18, 2008, 17,192 records of experimentally validated siRNAs, targeting 5,086 genes, originated from 6,122 independent studies are hosted in siRecords.
Synonyms: siRecords
Resource Type: data or information resource, database
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