KinMutBase: A registry of disease-causing mutations in protein kinase domains (RRID:SCR_007759)Copy Citation Copied
URL: http://www.uta.fi/imt/bioinfo/KinMutBase/
Proper Citation: KinMutBase: A registry of disease-causing mutations in protein kinase domains (RRID:SCR_007759)
Description: KinMutBase is a comprehensive database of disease-causing mutations in protein kinase domains. The current release of the database contains 582 mutations in 20 tyrosine kinase domains and 13 serine/threonine kinase domains. The database refers 1790 cases from 1322 families. KinMutBase is a registry of mutations in human protein kinases related to disorders. Kinases are essential cellular signaling molecules, in which mutations can lead to diseases, including immunodeficiencies, cancers and endocrine disorders. Mutations appear both in conserved hallmark residues of the kinases as well as in non-homologous sites. The KinMutBase WWW pages provide plenty of information, namely mutation statistics and display, clickable sequences with mutations and changes to restriction enzyme patterns.
Synonyms: KinmutBase
Resource Type: database, data or information resource
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