URL: http://prodoric.tu-bs.de/
Proper Citation: PRODORIC (RRID:SCR_007074)
Description: Database about gene regulation and gene expression in prokaryotes. It includes a manually curated and unique collection of transcription factor binding sites. A variety of bioinformatics tools for the prediction, analysis and visualization of regulons and gene reglulatory networks is included. The integrated approach provides information about molecular networks in prokaryotes with focus on pathogenic organisms. In detail this concerns: * transcriptional regulation (transcription factors and their DNA binding sites * signal transduction (two-component systems, phosphylation cascades) * protein interactions (complex formation, oligomerization) * biochemical pathways (chemical reactions) * other regulation events (e.g. codon usage, etc. ...) It aims to be a resource to model protein-host interactions and to be a suitable platform to analyze high-throughput data from proteomis and transcriptomics experiments (systems biology). Currently it mainly contains detailed information about operon and promoter structures including huge collections of transcription factor binding sites. If an appropriate number of regulatory binding sites is available, a position weight matrix (PWM) and a sequence logo is provided, which can be used to predict new binding sites. This data is collected manually by screening the original scientific literature. PRODORIC also handles protein-protein interactions and signal-transduction cascades that commonly occur in form of two-component systems in prokaryotes. Furthermore it contains metabolic network data imported from the KEGG database.
Abbreviations: PRODORIC
Synonyms: Prokaryotic Database of Gene Regulation
Resource Type: data or information resource, database
Defining Citation: PMID:18974177
Keywords: gene regulation, transcription factor binding site, promoter structure, gene expression, genome, regulon, network, visualization, gene regulatory network, pathogen, transcriptional regulation, transcription factor, dna binding site, signal transduction, protein interaction, pathway, regulation, protein-protein interaction, signal-transduction cascade, operon, promoter, structure, position weight matrix, FASEB list
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