URL: http://athina.biol.uoa.gr/bioinformatics/mcmbb/
Proper Citation: MCMBB (RRID:SCR_006198)
Description: A web tool used in the discrimination of beta-barrel outer membrane proteins with a Markov chain model. MCMBB is a fast algorithm, which discriminates beta-barrel outer membrane proteins from globular proteins and from alpha-helical membrane proteins. The algorithm is based on a 1st order Markov Chain model, which captures the alternating pattern of hydrophilic-hydrophobic residues occurring in the membrane-spanning beta-strands of beta-barrel outer membrane proteins. The model achieves high accuracy in discriminating outer membrane proteins, since it can discriminate beta-barrel outer membrane with a correct classification rate of 90.08% and the globular proteins with a correct classification rate of 92.67%. When submitting alpha-helical membrane proteins, the method shows an accuracy of 100%. A score greater than zero, indicates that the protein is more likely to be a beta-barrel outer membrane protein, whereas a result lower than zero, indicates that the protein is probable not a beta-barrel. You may enter up to 1000 sequences in Fasta format.
Abbreviations: MCMBB
Synonyms: MCMBB: Markov Chain Model for Beta Barrels
Resource Type: data analysis service, production service resource, analysis service resource, service resource
Keywords: algorithm, beta-barrel outer membrane protein, globular protein, alpha-helical membrane protein, markov chain model, beta-barrel, protein, outer membrane protein, classification, fasta, model
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University of Athens Biophysics and Bioinformatics Laboratory |
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