URL: http://www.rad.upenn.edu/sbia/
Proper Citation: Atrophy Simulation Package (RRID:SCR_006046)
Description: THIS RESOURCE IS NO LONGER IN SERVICE. Documented on June 2, 2023. Software package used to simulate brain images with local growth / atrophy within a prescribed spherical region. Specifically, given an input image and its segmented image, the location of the center of the spherical region, and the radius of that sphere, it simulates new images that have tissue growth or shrinkage within that pre-specified brain region according to given rates (atrophy for rates less than one and growth for rates greater than one). The algorithm uses an iterative procedure that tries to achieve the given level of volumetric change for brain tissues within the region, by seeking a smooth deformation field, whose Jacobian determinants match the prescribed volume change rate within the region. Note that in the current software, the simulation of growth or atrophy for brain tissue requires that the input spherical region has to cover some CSF or background regions.
Abbreviations: Atrophy Simulation
Resource Type: simulation software, software resource, software application
Defining Citation: PMID:15250639, PMID:16689268, PMID:16997578
Keywords: neuroimaging, brain, topology, atrophy, mri, deformation, image registration, brain modeling, biomedical imaging, volume measurement, model, morphology, tissue atrophy, brain tissue
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