URL: http://autosome.ru/HOCOMOCO/
Proper Citation: HOCOMOCO (RRID:SCR_005409)
Description: A comprehensive collection of human transcription factor binding sites models. DNA sequences of TF binding regions obtained by both pregenomic and high-throughput methods were collected from existing databases and other public data. The ChIPMunk software was used to construct positional weight matrices. Four motif discovery strategies were tested based on different motif shape priors including flat and periodic priors associated with DNA helix pitch. A quality rating was manually assigned to each model based on known binding preferences. An appropriate TFBS model was selected for each TF, with similar models selected for related TFs. In any case only one model per TF was selected unless there was additional evidence for two distinct binding models or different stable modes of dimerization. All TFBS models and initial binding segments data used for motif discovery were mapped to UniPROT IDs.
Abbreviations: HOCOMOCO
Synonyms: Homo Sapiens Comprehensive Model Collection (HOCOMOCO) of transcription factor (TF) binding models, Homo Sapiens Comprehensive Model Collection, Homo Sapiens Comprehensive Model Collection of transcription factor binding models
Resource Type: data or information resource, database
Defining Citation: PMID:23175603
Keywords: transcription factor, binding model, model, binding, FASEB list
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