URL: http://www.ucl.ac.uk/ion/departments/molecular/themes/neurodegeneration/brainbank
Proper Citation: Queen Square Brain Bank (RRID:SCR_004652)
Description: A brain bank which holds an archive of brains donated by individuals with neurodegenerative disease and others who serve as neurologically normal controls. It specializes in parkinsonian movement disorders, including Parkinson's disease and multiple system atrophy, and holds the national collection of brains donated by individuals with progressive supranuclear palsy (PSP). Recently the collection has been developed to include donated brains from prospectively studied people with familial dementias. The QSBB also banks brains donated by people with dystonia and Gilles de la Tourette syndrome. The Brain Bank aims to provide brain tissue for neuropathological studies and for scientific research both in the UK and worldwide. The large collection of tissue is backed up by clinical documentation and all material is fully evaluated by the neuropathologists at QSBB. Brain tissue is stored as formalin-fixed, wax embedded blocks and is frozen, either at -20 degrees C or at -80 degrees C (flash-frozen). Tissue can be provided as slide-mounted sections, or as small blocks for neurochemistry, proteomics and DNA and RNA analysis. Flash-frozen material has excellent histological preservation and is suitable for in situ hybridization and immunohistochemistry. Case-control studies are matched for post-mortem delay and agonal status and are supplied blind.
Abbreviations: QSBB
Synonyms: Queen Square Brain Bank for Neurological Disorders, UCL Brain Bank
Resource Type: material resource, biomaterial supply resource, tissue bank
Keywords: neurological disorder, parkinsons disease, clinical data, human brain, brain tissue, neurodegenerative disease, neurologically normal control, progressive supranuclear palsy, parkinsonian movement disorder, multiple system atrophy, dementia, dystonia, tourettes disorder
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