Accelerating Medicines Partnership Autoimmune Diseases of Rheumatoid Arthritis and Lupus (RRID:SCR_003731)Copy Citation Copied
URL: http://www.nih.gov/science/amp/autoimmune.htm
Proper Citation: Accelerating Medicines Partnership Autoimmune Diseases of Rheumatoid Arthritis and Lupus (RRID:SCR_003731)
Description: The autoimmune disease arm of the Accelerating Medicine Partnership (AMP), which aims to identify and validate the most promising biological targets of disease for new diagnostic and drug development, that is focused on rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). They seek to identify shared common flaws in inflammation, particularly those that are shared with a larger number of autoimmune disorders which can cause severe disability, greatly affect quality of life, and are associated with an increased risk of death. This project aims to reveal biomarkers and biological targets for drug development, matching existing drugs to patients with specific molecular profiles who are most likely to benefit. The research plan proposes a 5 year process. Year one will include startup activities such as validation of tissue acquisition processes and analytic technologies, and the development of operating procedures. The second year will focus on identification of disease specific pathways by comparing data from patients and healthy individuals. Years 3-5 will expand the scale to include comparisons of different subsets of patients with RA or lupus to allow molecularly based patient stratification for precise treatment. The final 12 months (2019) will also include preliminary target validation. The data will be made publicly available through an internet-based information portal.
Abbreviations: AMP Autoimmune, AMP RA/SLE
Synonyms: Accelerating Medicines Partnership - Autoimmune, AMP Autoimmune Diseases of Rheumatoid Arthritis and Lupus, AMP RA/SLE Program, Accelerating Medicines Partnership - Autoimmune Diseases, Accelerating Medicines Partnership - Arthritis, AMP Rheumatoid arthritis and lupus, Accelerating Medicines Partnership - Autoimmune Diseases of Rheumatoid Arthritis and Lupus
Resource Type: consortium, portal, organization portal, data or information resource
Keywords: drug, drug development, biomarker, data sharing, consortium, gene expression, signaling, tissue, organ, synovium, kidney, skin, blood cell, inflammation
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