URL: http://ucsfeye.net/mlavailRDratmodels.shtml
Proper Citation: Retinal Degeneration Rat Model Resource (RRID:SCR_003311)
Description: Supplier of fully penetrant rat models of the retinitis pigmentosa type of inherited retinal degeneration, including the following models: * Mutant rhodopsin transgenic rats ** P23H mutant rhodopsin transgenic rats -Three lines with different rates of photoreceptor degeneration ** S334ter mutant rhodopsin transgenic rats -Five lines with different rates of photoreceptor degeneration * RCS (Royal College of Surgeons) rats with inherited retinal dystrophy ** RCS pink-eyed inbred strain ** RCS pigmented congenic strain with slowed rate of retinal dystrophy ** RCS congenic control strains of both pigmentation types, wild-type at the retinal dystrophy (Mertk) genetic locus The resource has been supported by the National Eye Institute (NEI) for the past 19 years to produce and distribute breeding pairs of these animal models to vision scientists. Thus, the following apply: * Request for rats requires only a 1-page letter/e-mail addressing 4 questions * No charge for the animals or tissues (except for shipping costs) * No Material Transfer Agreement (MTA) required * No collaboration requirement (in most cases) The resource usually provides multiple breeding pairs of the rats to vision scientists to generate breeding stock. It can also provide extra animals to breed for immediate experimental work, animals of specific ages (depending upon availability), animals with prior exposure to different lighting conditions, eyes taken at specific ages instead of rats for pilot studies and other experiments (fresh, frozen, dissected in specific ways, or fixed with special fixatives or by different methods), or other tissues (e.g., liver, spleen, brain, testis, etc.) prepared different ways.
Abbreviations: Retinal Degeneration Rat Model Resource
Synonyms: NEI Retinal Degeneration Rat Model Resource
Resource Type: organism supplier, biomaterial supply resource, material resource
Keywords: mutant rhodopsin transgenic rat, p23h mutant rhodopsin transgenic rat, s334ter mutant rhodopsin transgenic rat, rcs inbred, congenic strain, retinitis pigmentosa, retinal degeneration, retinal dystrophy, vision, rat, eye, transgenic rat, retina, model organism, mutant rat
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