URL: http://dbtbs.hgc.jp/
Proper Citation: DBTBS (RRID:SCR_002345)
Description: Database of experimentally validated gene regulatory relations and the corresponding transcription factor binding sites upstream of Bacillus subtilis genes. The database allows the comparison of systematic experiments with individual experimental results in order to facilitate the elucidation of the complete B. subtilis gene regulatory network. The current version is constructed by surveying 947 references and contains the information of 120 binding factors and 1475 gene regulatory relations. For each promoter, all of its known cis-elements are listed according to their positions, while these cis-elements are aligned to illustrate the consensus sequence for each transcription factor. All probable transcription factors coded in the genome were classified using Pfam motifs. The DBTBS database was reorganized to show operons instead of individual genes as the building blocks of gene regulatory networks. It now contains 463 experimentally known operons, as well as their terminator sequences if identifiable. In addition, 517 transcriptional terminators were identified computationally. (De Hoon, M.J.L. et al., PLoS Comput. Biol. 1, e25 (2005)). A new section was added under "Motif conservation", which presents hexameric motifs found to be conserved to different extents between upstream intergenic regions of genus-specific subgroups of homologous proteins.
Abbreviations: DBTBS
Synonyms: DBTBS: a database of Bacillus subtilis promoters and transcription factors., DBTBS: a database of Bacillus subtilis promoters and transcription factors
Resource Type: data or information resource, database
Defining Citation: PMID:17962296, PMID:14681362, PMID:11125112
Keywords: gene, gene regulatory network, transcription factor binding site, transcription factor, regulated operon, motif, promoter, motif conservation
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