URL: https://www.niddkrepository.org/studies/halt-pkd/
Proper Citation: HALT PKD (RRID:SCR_001529)
Description: Consortium established to design and implement clinical trials of treatments that might slow the progressive loss of renal function in Polycystic Kidney Disease (PKD). Two multicenter randomized, double-blind, placebo controlled clinical trials are running concurrently to study the efficacy of renin-angiotensin-aldosterone system blockade on the progression of cystic disease (kidney volume) and on the decline in renal function in autosomal dominant polycystic kidney disease (ADPKD). Study A is to study whether intensive ACE-I/ARB blockade decrease the progression of cystic disease compared to ACE-I monotherapy patients with early disease, relatively preserved renal function, and high-normal BP or hypertension. Study B is to study whether intensive ACE-I/ARB blockade as compared to ACE-I monotherapy slow the decline in kidney function, end-stage of renal disease, or death in the setting of standard blood pressure control in hypertensive patients with moderately advanced disease.
Abbreviations: HALT PKD, HALT-PKD
Synonyms: Polycystic Kidney Disease-Treatment Network
Resource Type: resource, clinical trial
Keywords: treatment, renal function, lisinopril, placebo, telmisartan, male, female, adolescent, adult human
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Washington University School of Medicine in St. Louis; Missouri; USA |
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