URL: https://www.niddkrepository.org/niddk/jsp/public/dataset.jsp#DPT-1
Proper Citation: Diabetes Prevention Type 1 (RRID:SCR_001467)
Description: Data set and biosepecimens of a multi-center clinical trial to determine if treatment with beta-cell antigens can delay the onset of Type 1 Diabetes Mellitus (Type 1 DM) in non-diabetic relatives of persons with Type 1 DM. Insulin is a well characterized antigen specifically produced by beta-cells, and it was used for this purpose in the initial DPT-1 studies. The protocol for high risk subjects uses daily subcutaneous insulin injections and an annual course of intravenous insulin treatment, while the protocol for intermediate risk subjects uses daily doses of insulin administered orally. Neither injected nor oral insulin at the doses used were observed to delay or prevent diabetes, although further studies are needed to test whether oral insulin can delay diabetes in people in the intermediate risk group with high titers of insulin autoantibodies.
Abbreviations: DPT-1
Synonyms: Diabetes Prevention Trial--Type 1 (DPT-1) dataset, DPT-1 (The Diabetes Prevention Type 1)
Resource Type: biomaterial supply resource, material resource
Keywords: beta cell antigen, insulin, prevention, onset, subcutaneous injection, oral, intravenous, treatment, randomized, controlled trial, drug therapy, delay
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