URL: http://bussemakerlab.org/YeastTransfactomeDB/
Proper Citation: Yeast Transfactome Database (RRID:SCR_000599)
Description: THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 15, 2013. A repository of sequence specificity models and condition-specific regulatory activities for a large number of DNA- and RNA-binding proteins in Saccharomyces cerevisiae. Accurate and comprehensive information about the nucleotide sequence specificity of trans-acting factors (TFs) is essential for computational and experimental analyses of gene regulatory networks. The sequence specificities in TransfactomeDB, represented as position-specific affinity matrices (PSAMs), are directly estimated from genomewide measurements of TF-binding using our previously published MatrixREDUCE algorithm, which is based on a biophysical model. For each mRNA expression profile in the NCBI Gene Expression Omnibus, we used sequence-based regression analysis to estimate the post-translational regulatory activity of each TF for which a PSAM is available. The trans-factor activity profiles across multiple experiments available in TransfactomeDB allow the user to explore potential regulatory roles of hundreds of TFs in any of thousands of microarray experiments.
Synonyms: TransfactomeDB, Yeast Transfactome Database
Resource Type: data or information resource, database
Defining Citation: PMID:17947326
Keywords: mrna, position-specific affinity matrices, saccharomyces cerevisiae
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