URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=13602097
Proper Citation: RRID:RRRC_00834
Description: Rattus norvegicus with name LE.Cg-(ROSA26) em1(CAG-Cas9*D10A)Ottc from RGD.
Species: Rattus norvegicus
Notes: This mutant strain was created using highly efficient CRISPR-Cas9-mediated homology-directed repair (HDR) in rat spermatogonial stem cell cultures. The CRISPR/Case9 knock-in rats have cre recombinase-dependent expression of CRISPR associated protein 9 (Cas9) catalytic mutant protein D10A under the control of CAG promoter inserted to the rat ROSA26 locus. ROSA26 is a synonym for rat Thumpd3-as1 (RGD:6491660) and is used as an official symbol for rat strain nomenclature.The resulting mutant rats in Prague-Dawley background was backcrossed with WT LE for three or four generations for studies. Rat Resource and Research Center
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Source: Integrated Animals
Source Database: Rat Resource and Research Center (RRRC)
