Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility (RRID:SCR_017768)Copy Citation Copied
URL: http://www.feinberg.northwestern.edu/research/cores/units/clin-pharm.html
Proper Citation: Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility (RRID:SCR_017768)
Description: Core provides quantitative mass spectrometry based support for in vitro studies and both preclinical and clinical studies of variety of small molecules, including cancer chemotherapeutic agents, analgesics, and antidepressants. Expertise includes optimizing design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies. Helps with biological sample preparation, quantitative mass spectrometric drug concentration measurement, and drug concentration versus time data modeling. Small molecule concentrations in plasma and other body fluids are measured using Sciex 6500 QTrap with UPLC and nano LC or an Agilent HPLC system linked to Applied Biosystems API 3000 triple quadrupole mass spectrometer after sample preparation by, for example, solid-phase extraction. Drug concentration versus time relationships are fitted to various compartmental pharmacokinetic models using commercially available and specialized software.
Synonyms: Mary Beth Donnelley Clinical Pharmacology Core Facility
Resource Type: access service resource, core facility, service resource
Keywords: Clinical, pre clinical, pharmacology, quantitative, mass, spectrometry, cancer, chemotherapeutic, agent, analgesic, antidepressant, design, analysis, pharmacokinetic, study, drug, concentratiion, measure, sample, preparation, service, core
Funding: OD S10 OD021786
Availability: Restricted
Resource Name: Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility
Resource ID: SCR_017768
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Source: SciCrunch Registry (RRID:SCR_005400)
Description: Interactive portal for finding and submitting biomedical resources. Resources within SciCrunch have assigned RRIDs which are used to cite resources in scientific manuscripts. SciCrunch Registry, formerly NIF Registry, provides resources catalog. Allows to add new resources. Allows edit existing resources after registration. Curators are tasked with identifying and registering resources, examining data, writing configuration files to index and display data and keeping contents current.
URL: https://rrid.site/rin/sources/SCR_005400
