Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility (RRID:SCR_017768)Copy Citation Copied
URL: http://www.feinberg.northwestern.edu/research/cores/units/clin-pharm.html
Proper Citation: Northwestern University Mary Beth Donnelley Clinical Pharmacology Core Facility (RRID:SCR_017768)
Description: Core provides quantitative mass spectrometry based support for in vitro studies and both preclinical and clinical studies of variety of small molecules, including cancer chemotherapeutic agents, analgesics, and antidepressants. Expertise includes optimizing design, conduct, analysis, interpretation, and reportage of pharmacokinetic studies. Helps with biological sample preparation, quantitative mass spectrometric drug concentration measurement, and drug concentration versus time data modeling. Small molecule concentrations in plasma and other body fluids are measured using Sciex 6500 QTrap with UPLC and nano LC or an Agilent HPLC system linked to Applied Biosystems API 3000 triple quadrupole mass spectrometer after sample preparation by, for example, solid-phase extraction. Drug concentration versus time relationships are fitted to various compartmental pharmacokinetic models using commercially available and specialized software.
Synonyms: Mary Beth Donnelley Clinical Pharmacology Core Facility
Resource Type: core facility, access service resource, service resource
Keywords: Clinical, pre clinical, pharmacology, quantitative, mass, spectrometry, cancer, chemotherapeutic, agent, analgesic, antidepressant, design, analysis, pharmacokinetic, study, drug, concentratiion, measure, sample, preparation, service, core
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