URL: http://ecid.bioinfo.cnio.es/
Proper Citation: E. coli Interaction Database (RRID:SCR_007635)
Description: The EcID database (E. coli Interaction Database) provides a common framework for exploring the sizeable amount of protein interaction-related data available for Escherichia coli. EcID integrates information related with functional interactions extracted from the following sources: EcoCyc (metabolic pathways, protein complexes and regulatory information) KEGG (metabolic pathways) and MINT (protein interactions). :It also contains information on protein complexes from the two published high throughput pull down experiments carried out in E. coli, and potential interactions directly extracted from the literature using the web-services associated to the iHOP text-mining system. Additionally, EcID incorporates results from two protein interaction prediction methods based on genomic information (Phylogenetic Profiles and Gene Neighborhoods) and three methods based on analysis of the potential co-evolution of the corresponding protein families (Mirror Tree, In Silico 2 Hybrid and Context Mirror). EcID associates to each predicted pair a confidence score that reflects the reliability of the functional interaction between those two proteins. :In order to provide a global score to combine the predictive power of the prediction methods described above we have integrated in EcID a Bayesian-based classifier. This method includes the scores of five different prediction methods (Phylogenetic Profiles, Gene Neighborhood, Gene Fusion, Mirror Tree and In Silico 2 Hybrid), together with information on a number of simple sequence features. The classifier was trained to predict the type of protein functional associations contained in EcID (derived from regulation data, biochemical pathways, protein complexes and protein physical interactions).
Synonyms: EcID
Resource Type: data or information resource, database
Keywords: e. coli, e. coli protein, e. coli protein interaction
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