URL: https://web.expasy.org/cellosaurus/CVCL_JF22
Proper Citation: RRID:CVCL_JF22
Description: Cell line A-375 NRAS p.Q61K is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Female
Disease: Amelanotic melanoma
Comments: Characteristics: Shows significant resistance to the BRAF inhibitors Dabrafineb and Vemurafenib when compared to its parental cell line in 2D and 3D culture systems. Can be a useful model to study the RAS-RAF-MEK-ERK-MAP kinase signaling pathway and to screen potential BRAF inhibitors and anti-cancer compounds for drug discovery and development (ATCC=CRL-1619IG-2)., Population: Caucasian.
Category: Cancer cell line
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Source: Cellosaurus
