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TER-119/Erythroid cells antibody

RRID:AB_398635

Antibody ID

AB_398635

Target Antigen

TER-119/Erythroid cells mouse

Proper Citation

(BD Biosciences Cat# 557909, RRID:AB_398635)

Clonality

monoclonal antibody

Comments

Flow cytometry

Host Organism

rat

Vendor

BD Biosciences Go To Vendor

Cat Num

557909

Publications that use this research resource

Hedgehog Pathway Drives Fusion-Negative Rhabdomyosarcoma Initiated From Non-myogenic Endothelial Progenitors.

  • Drummond CJ
  • Cancer Cell
  • 2018 Jan 8

Literature context:


Abstract:

Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that histologically resembles embryonic skeletal muscle. RMS occurs throughout the body and an exclusively myogenic origin does not account for RMS occurring in sites devoid of skeletal muscle. We previously described an RMS model activating a conditional constitutively active Smoothened mutant (SmoM2) with aP2-Cre. Using genetic fate mapping, we show SmoM2 expression in Cre-expressing endothelial progenitors results in myogenic transdifferentiation and RMS. We show that endothelium and skeletal muscle within the head and neck arise from Kdr-expressing progenitors, and that hedgehog pathway activation results in aberrant expression of myogenic specification factors as a potential mechanism driving RMS genesis. These findings suggest that RMS can originate from aberrant development of non-myogenic cells.

Funding information:
  • NCI NIH HHS - K08 CA151649()
  • NCI NIH HHS - P30 CA021765()
  • NCI NIH HHS - R01 CA216344()
  • NIAID NIH HHS - R21AI094333(United States)

Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.

  • Lee JH
  • Cell
  • 2017 Sep 7

Literature context:


Abstract:

The diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA sequencing, and organoid culture approaches to show that Lgr5 and Lgr6, well-known markers of stem cells in epithelial tissues, are markers of mesenchymal cells in the adult lung. Lgr6+ cells comprise a subpopulation of smooth muscle cells surrounding airway epithelia and promote airway differentiation of epithelial progenitors via Wnt-Fgf10 cooperation. Genetic ablation of Lgr6+ cells impairs airway injury repair in vivo. Distinct Lgr5+ cells are located in alveolar compartments and are sufficient to promote alveolar differentiation of epithelial progenitors through Wnt activation. Modulating Wnt activity altered differentiation outcomes specified by mesenchymal cells. This identification of region- and lineage-specific crosstalk between epithelium and their neighboring mesenchymal partners provides new understanding of how different cell types are maintained in the adult lung.

Funding information:
  • NCI NIH HHS - K99 CA187317()
  • NCI NIH HHS - P30 CA014051()
  • NCI NIH HHS - U24 CA180922()
  • NHLBI NIH HHS - R01 HL090136()
  • NHLBI NIH HHS - R01 HL125821()
  • NHLBI NIH HHS - U01 HL100402()
  • Wellcome Trust - R01 HL132266()