URL: http://antibodyregistry.org/AB_2832939
Proper Citation: (Nicholas M. Kanaan at Michigan State University Cat# TOC1, RRID:AB_2832939)
Target Antigen: Oligomeric tau
Host Organism: mouse
Clonality: monoclonal
Comments: Originally developed and characterized by Dr. Lester I. Binder at Northwestern University. The TOC1 antibody selectively recognizes oligomeric species of tau. The antibody was generated against cross-linked human tau dimers and originally the epitope was thought be a discontinuous epitope between amino acids 155-244 and 376-421 of full-length human tau (see Patterson et al., PMID: 21550980). However, more recent characterization of TOC1 indicates that the epitope is between aa 209-224 (see Ward et al., PMID: 23979027). Since the TOC1 epitope is continuous/linear, it must be used in non-denaturing assays such as dot blots, sandwich ELISAs and/or tissue immunostaining. TOC1: characterization of a selective oligomeric tau antibody. Initial characterizing report: Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, Ward S, Reyes JF, Philibert K, Glucksman MJ, Binder LI. Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem. 2011; 286(26):23063-76. PMID:21550980; PMCID: PMC3123074. Final Epitope Determination: Ward SM, Himmelstein DS, Lancia JK, Fu Y, Patterson KR, Binder LI. J Alzheimers Dis. 2013; 37 (3): 593–602. PMID: 23979027.
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Source: Antibody Registry
