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NBP2-17218 MAP3K12 Antibody

RRID:AB_2650533

Antibody ID

AB_2650533

Target Antigen

MAP3K12 human, mouse, rat

Proper Citation

(Novus Cat# NBP2-17218, RRID:AB_2650533)

Clonality

polyclonal antibody

Reference

PMID:28641113

Host Organism

rabbit

Vendor

Novus

Cat Num

NBP2-17218

Publications that use this research resource

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

  • Welsbie DS
  • Neuron
  • 2017 Jun 21

Literature context:


Abstract:

Dual leucine zipper kinase (DLK) has been implicated in cell death signaling secondary to axonal damage in retinal ganglion cells (RGCs) and other neurons. To better understand the pathway through which DLK acts, we developed enhanced functional genomic screens in primary RGCs, including use of arrayed, whole-genome, small interfering RNA libraries. Explaining why DLK inhibition is only partially protective, we identify leucine zipper kinase (LZK) as cooperating with DLK to activate downstream signaling and cell death in RGCs, including in a mouse model of optic nerve injury, and show that the same pathway is active in human stem cell-derived RGCs. Moreover, we identify four transcription factors, JUN, activating transcription factor 2 (ATF2), myocyte-specific enhancer factor 2A (MEF2A), and SRY-Box 11 (SOX11), as being the major downstream mediators through which DLK/LZK activation leads to RGC cell death. Increased understanding of the DLK pathway has implications for understanding and treating neurodegenerative diseases.