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GAPDH Loading Control Monoclonal Antibody (GA1R)

RRID:AB_2537652

Antibody ID

AB_2537652

Target Antigen

GAPDH Loading Control human

Proper Citation

(Thermo Fisher Scientific Cat# MA5-15738-1MG, RRID:AB_2537652)

Clonality

monoclonal antibody

Comments

Applications: ICC (1:20-1:200), IHC (P) (1:50-1:500), WB (1:1000-1:10,000), IF (1:20-1:200), ELISA (Assay Dependent), Flow (2 µg/test)

Clone ID

Clone GA1R

Host Organism

mouse

Vendor

Thermo Fisher Scientific Go To Vendor

Cat Num

MA5-15738-1MG

Publications that use this research resource

Different Neuronal Activity Patterns Induce Different Gene Expression Programs.

  • Tyssowski KM
  • Neuron
  • 2018 May 2

Literature context:


Abstract:

A vast number of different neuronal activity patterns could each induce a different set of activity-regulated genes. Mapping this coupling between activity pattern and gene induction would allow inference of a neuron's activity-pattern history from its gene expression and improve our understanding of activity-pattern-dependent synaptic plasticity. In genome-scale experiments comparing brief and sustained activity patterns, we reveal that activity-duration history can be inferred from gene expression profiles. Brief activity selectively induces a small subset of the activity-regulated gene program that corresponds to the first of three temporal waves of genes induced by sustained activity. Induction of these first-wave genes is mechanistically distinct from that of the later waves because it requires MAPK/ERK signaling but does not require de novo translation. Thus, the same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations.

Funding information:
  • Cancer Research UK - C20691/A11834(United Kingdom)