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Rabbit Anti-Human c-Ret Monoclonal Antibody, Unconjugated, Clone R787

RRID:AB_2301042

Antibody ID

AB_2301042

Target Antigen

RET human

Proper Citation

(Immuno-Biological Laboratories Cat# 18121, RRID:AB_2301042)

Clonality

monoclonal antibody

Reference

PMID:29022879

Comments

Useful for

Host Organism

rabbit

Vendor

Immuno-Biological Laboratories

Cat Num

18121

Publications that use this research resource

Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors.

  • Olson W
  • Elife
  • 2017 Oct 12

Literature context:


Abstract:

The human distal limbs have a high spatial acuity for noxious stimuli but a low density of pain-sensing neurites. To elucidate mechanisms underlying regional differences in processing nociception, we sparsely traced non-peptidergic nociceptors across the body using a newly generated MrgprdCreERT2 mouse line. We found that mouse plantar paw skin is also innervated by a low density of Mrgprd+ nociceptors, while individual arbors in different locations are comparable in size. Surprisingly, the central arbors of plantar paw and trunk innervating nociceptors have distinct morphologies in the spinal cord. This regional difference is well correlated with a heightened signal transmission for plantar paw circuits, as revealed by both spinal cord slice recordings and behavior assays. Taken together, our results elucidate a novel somatotopic functional organization of the mammalian pain system and suggest that regional central arbor structure could facilitate the "enlarged representation" of plantar paw regions in the CNS.

Funding information:
  • NIGMS NIH HHS - K12 GM081259()
  • NINDS NIH HHS - F31 NS092297()
  • NINDS NIH HHS - R01 NS083702()
  • NINDS NIH HHS - R01 NS094224()