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Anti-Arc antibody

RRID:AB_2151848

Antibody ID

AB_2151848

Target Antigen

Arc rat, mouse

Proper Citation

(Synaptic Systems Cat# 156 005, RRID:AB_2151848)

Clonality

polyclonal antibody

Comments

Applications: WB ICC IHC

Host Organism

guinea pig

Vendor

Synaptic Systems Go To Vendor

Cat Num

156 005

Publications that use this research resource

Different Neuronal Activity Patterns Induce Different Gene Expression Programs.

  • Tyssowski KM
  • Neuron
  • 2018 May 2

Literature context:


Abstract:

A vast number of different neuronal activity patterns could each induce a different set of activity-regulated genes. Mapping this coupling between activity pattern and gene induction would allow inference of a neuron's activity-pattern history from its gene expression and improve our understanding of activity-pattern-dependent synaptic plasticity. In genome-scale experiments comparing brief and sustained activity patterns, we reveal that activity-duration history can be inferred from gene expression profiles. Brief activity selectively induces a small subset of the activity-regulated gene program that corresponds to the first of three temporal waves of genes induced by sustained activity. Induction of these first-wave genes is mechanistically distinct from that of the later waves because it requires MAPK/ERK signaling but does not require de novo translation. Thus, the same mechanisms that establish the multi-wave temporal structure of gene induction also enable different gene sets to be induced by different activity durations.

Funding information:
  • Cancer Research UK - C20691/A11834(United Kingdom)