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Rabbit Anti-Tubulin, delta 2 , Unconjugated antibody

RRID:AB_177351

Antibody ID

AB_177351

Target Antigen

Tubulin, delta 2 bovine, canine, donkey, feline, guinea pig, hamster, horse, human, mouse, other, porcine, rabbit, rat, sheep, simian, mammals, green plants

Proper Citation

(Millipore Cat# AB3203, RRID:AB_177351)

Clonality

unknown

Comments

seller recommendations: Electron Microscopy, Western Blotting

Host Organism

rabbit

Vendor

Millipore

Cat Num

AB3203

Publications that use this research resource

Differentiation between Oppositely Oriented Microtubules Controls Polarized Neuronal Transport.

  • Tas RP
  • Neuron
  • 2017 Dec 20

Literature context:


Abstract:

Microtubules are essential for polarized transport in neurons, but how their organization guides motor proteins to axons or dendrites is unclear. Because different motors recognize distinct microtubule properties, we used optical nanoscopy to examine the relationship between microtubule orientations, stability, and modifications. Nanometric tracking of motors to super-resolve microtubules and determine their polarity revealed that in dendrites, stable and acetylated microtubules are mostly oriented minus-end out, while dynamic and tyrosinated microtubules are oriented oppositely. In addition, microtubules with similar orientations and modifications form bundles that bias transport. Importantly, because the plus-end-directed Kinesin-1 selectively interacts with acetylated microtubules, this organization guides this motor out of dendrites and into axons. In contrast, Kinesin-3 prefers tyrosinated microtubules and can enter both axons and dendrites. This separation of distinct microtubule subsets into oppositely oriented bundles constitutes a key architectural principle of the neuronal microtubule cytoskeleton that enables polarized sorting by different motor proteins.

Funding information:
  • Medical Research Council - G0901533(United Kingdom)

Erratum to: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament.

  • Kadam PD
  • Int Urogynecol J
  • 2016 Mar 25

Literature context:


Abstract:

There was an oversight in the Authorship of a recent Images in Urogynecology article titled: Rectocutaneous fistula with transmigration of the suture: a rare delayed complication of vault fixation with the sacrospinous ligament (DOI 10.1007/ s00192-015-2823-5). We would like to include Adj A/P Han How Chuan’s name in the list of authors. Adj A/P Han is a Senior Consultant and Department Head of Urogynaecology at the KK Hospital for Women and Children, Singapore.

Funding information:
  • NHGRI NIH HHS - R01HG005855(United States)