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Protocol for behavioral and neural recording in macaques during a novelty detection task.

Xinyu Du | Peirun Song | Yumei Gong | Yuying Zhai | Haoxuan Xu | Hangting Ye | Xuehui Bao | Qianyue Huang | Zhiyi Tu | Pei Chen | Xuan Zhao | David Pérez-González | Manuel S Malmierca | Xiongjie Yu
STAR protocols | 2024

The neural mechanisms of novelty detection, especially in relation to behavior, are currently poorly understood. Here, we present a protocol for recording neuronal activity in macaque auditory cortex during novelty detection tasks. We describe steps for behavioral training, surgical headpost implantation, MRI-based electrode targeting, and electrophysiological recording. These steps allow direct assessment of the correlation between novelty detection behavior and neuronal activity. For complete details on the use and execution of this protocol, please refer to Gong et al.1.

Pubmed ID: 39126655 RIS Download

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RZ6 Multi-I/O Processor (tool)

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