Brain intratumoural astatine-211 radiotherapy targeting syndecan-1 leads to durable glioblastoma remission and immune memory in female mice.
Glioblastoma (GB), the most aggressive brain cancer, remains a critical clinical challenge due to its resistance to conventional treatments. Here, we introduce a locoregional targeted-α-therapy (TAT) with the rat monoclonal antibody 9E7.4 targeting murine syndecan-1 (SDC1) coupled to the α-emitter radionuclide astatine-211 (211At-9E7.4).
Pubmed ID: 38905749 RIS Download
Research resources used in this publication
Additional research tools detected in this publication
Antibodies used in this publication
- CD3e Monoclonal Antibody (145-2C11), FITC, eBioscience (RRID:AB_464882)
- Rat Anti-CD62L Monoclonal Antibody, Allophycocyanin Conjugated, Clone MEL-14 (RRID:AB_398533)
- CD44 (RRID:AB_2738011)
- CD8a Monoclonal Antibody (53-6.7), APC-eFluor™ 780, eBioscience (RRID:AB_1272185)
- Rat Anti-CD4 Monoclonal Antibody, PE-Cy7 Conjugated, Clone RM4-5 (RRID:AB_394461)
- Goat Anti-Rabbit IgG Antibody (H+L), Biotinylated (RRID:AB_2313606)
- Goat Anti-Rat IgG Antibody (H+L), Biotinylated (RRID:AB_3073814)
- Rat IgG2b, k (RRID:AB_10056899)
- Rat IgG2a, kappa Isotype Control, Unconjugated, Clone R35-95 (RRID:AB_395142)
- CD45 Antibody, anti-mouse, VioGreen™, REAfinity™ (RRID:AB_2658224)
- Goat Anti-Rat IgG (H+L) Antibody, Alexa Fluor ?? 546 Conjugated (RRID:AB_141738)
- CD8a Monoclonal Antibody (53-6.7), eBioscience (RRID:AB_467087)
- CD3 Monoclonal Antibody (17A2), eBioscience (RRID:AB_467053)
- CD4 Monoclonal Antibody (GK1.5), eBioscience (RRID:AB_467063)
- CD11b Monoclonal Antibody (M1/70), eBioscience (RRID:AB_467108)
- M.O.M. Anti-Mouse Ig Reagent (RRID:AB_2336564)
- CD45 Monoclonal Antibody (30-F11), eBioscience (RRID:AB_467251)
- CD31 (RRID:AB_393571)
Associated grants
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This is a list of tools and resources that we have found mentioned in this publication.
Fiji (tool)
RRID:SCR_002285
Software package as distribution of ImageJ and ImageJ2 together with Java, Java3D and plugins organized into coherent menu structure. Used to assist research in life sciences.
View all literature mentionsFlowJo (tool)
RRID:SCR_008520
Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsDako (tool)
RRID:SCR_013530
An Antibody supplier; Dako was purchased by Agilent in 2012 and several years later the websites began to reflect the Dako products as part of the Agilent catalog.
View all literature mentionsBiorender (tool)
RRID:SCR_018361
Web tool for graphical illustrations for biological systems by BioRender. Used for articles and presentations. Collection of pre made icons and templates from life science fields for scientific illustrations. Customized icons possible on request.
View all literature mentionsGlioVis (tool)
RRID:SCR_023877
Web application for data visualization and analysis to explore brain tumors expression datasets.
View all literature mentionsCD3e Monoclonal Antibody (145-2C11), FITC, eBioscience (antibody)
RRID:AB_464882
This monoclonal targets CD3e
View all literature mentionsRat Anti-CD62L Monoclonal Antibody, Allophycocyanin Conjugated, Clone MEL-14 (antibody)
RRID:AB_398533
This monoclonal targets CD62L
View all literature mentionsCD8a Monoclonal Antibody (53-6.7), APC-eFluor™ 780, eBioscience (antibody)
RRID:AB_1272185
This monoclonal targets CD8a
View all literature mentionsRat Anti-CD4 Monoclonal Antibody, PE-Cy7 Conjugated, Clone RM4-5 (antibody)
RRID:AB_394461
This monoclonal targets CD4
View all literature mentionsGoat Anti-Rabbit IgG Antibody (H+L), Biotinylated (antibody)
RRID:AB_2313606
This polyclonal targets IgG
View all literature mentionsGoat Anti-Rat IgG Antibody (H+L), Biotinylated (antibody)
RRID:AB_3073814
This polyclonal secondary targets IgG (H+L)
View all literature mentionsRat IgG2b, k (antibody)
RRID:AB_10056899
This monoclonal targets Rat IgG2b k
View all literature mentionsRat IgG2a, kappa Isotype Control, Unconjugated, Clone R35-95 (antibody)
RRID:AB_395142
This unknown targets Rat IgG2a kappa Isotype Control Clone R35-95
View all literature mentionsCD45 Antibody, anti-mouse, VioGreen™, REAfinity™ (antibody)
RRID:AB_2658224
This recombinant monoclonal targets CD45
View all literature mentionsGoat Anti-Rat IgG (H+L) Antibody, Alexa Fluor ?? 546 Conjugated (antibody)
RRID:AB_141738
This unknown targets Rat IgG (H+L)
View all literature mentionsCD8a Monoclonal Antibody (53-6.7), eBioscience (antibody)
RRID:AB_467087
This monoclonal targets CD8a
View all literature mentionsCD3 Monoclonal Antibody (17A2), eBioscience (antibody)
RRID:AB_467053
This monoclonal targets CD3
View all literature mentionsCD4 Monoclonal Antibody (GK1.5), eBioscience (antibody)
RRID:AB_467063
This monoclonal targets CD4
View all literature mentionsCD11b Monoclonal Antibody (M1/70), eBioscience (antibody)
RRID:AB_467108
This monoclonal targets CD11b
View all literature mentionsM.O.M. Anti-Mouse Ig Reagent (antibody)
RRID:AB_2336564
This unknown targets
View all literature mentionsCD45 Monoclonal Antibody (30-F11), eBioscience (antibody)
RRID:AB_467251
This monoclonal targets CD45
View all literature mentionsGL261 (cell line)
RRID:CVCL_Y003
Cell line GL261 is a Cancer cell line with a species of origin Mus musculus (Mouse)
View all literature mentionsC57BL/6JRj (organism)
RRID:MGI:2670020
laboratory mouse with name C57BL/6JRj from MGI.
View all literature mentions
